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Lentinan is a beta-glucan with a glycosidic β-1,3:β-1,6 linkage.[1] It is an anti-tumor polysaccharide from the shiitake (Lentinula edodes) mushroom.[1] Lentinan is a polysaccharide that has a molecular weight of approximately 500,000 Da. The Japanese pharmaceutical company Ajinomoto developed Lentinan, which is an intravenously administered anti-cancer agent.[1]

Lentinan is one of the host-mediated anti-cancer drugs[2] which has been shown to affect host defense immune systems.[3]


Research into the effects of Lentinan

Lentinex is a formulation featuring lentinan and is approved for use in the EU. An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937.[4] A pharmacological blend (MC-S) of lentinan, PSK, Ganoderma lucidum and Astragalus propinquus has also been shown to stimulate white blood cell production in vitro. [5]

An in vivo experiment on mice, revealed lentinan is orally active (since clinical use of the drug is administered through an IV). [6]

Limited clinical studies of cancer patients have associated lentinan with a higher survival rate, higher quality of life, and lower re-occurrence of cancer.

Written on February 11th, 2012 , Botany, Mycology Tags:

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